Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling SATB2: MIM i: 119540, phenotype 608148, gene: neXtProt i: NX_Q9UPW6: OpenTargets i: ENSG00000119042: Orphanet i: 251019, 2q32q33 microdeletion syndrome 251028, SATB2-associated syndrome due to a chromosomal rearrangement 576283, SATB2-associated syndrome due to a pathogenic variant: PharmGKB i: PA128394624: VEuPathDB i: HostDB:ENSG00000119042.16 The SATB2 gene provides instructions for making a protein that helps control the development of certain body systems. The SATB2 protein attaches to special regions of DNA called matrix attachment regions (MARs). These regions help determine the structure of chromatin, which is the complex of DNA and proteins that packages DNA into chromosomes. SATB2_ENST00000260926, SATB2_ENST00000443023, SATB2_ENST00000457245, SATB2_ENST00000614512, SATB2_ENST00000428695 Sequences You can see various sequences for this gene: cDNA (ENST00000417098.5) Protein (SATB2) Transcript and protein aligned (ENST00000417098.5+SATB2) Gene fusions No fusions involving SATB2 Drug sensitivity data n/a SATB2 SATB homeobox 2.
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Testis, 4-5. Colon adenocarcinoma, 6. Colon neuroendocrine tumour, 7. Ovarian mucinous adenocarcinoma. All tissues were fixed in 10% neutral buffered formalin.
Cited in 30 publication(s). and SATB2 expression in periampullary adenocarcinoma has not yet been described.
It can act not only as an activating or repressing DNA bound protein but also 22 Sep 2019 But the eight-year-old is also the only child in the state diagnosed with a rare genetic disorder. Sadie was just two when diagnosed with SATB2, SATB2-associated syndrome (SAS) is a multisystemic disorder caused by alterations of the SATB2 gene. We describe the phenotype and genotype of twelve 26 Jan 2016 SATB2 acts as a tumor suppressor in laryngeal squamous cell carcinoma and colon cancer, whereas SATB1 promotes the progression of 15 Jul 2019 SATB2 subsequently recruited HDAC1 to the Snail promoter, repressing Snail transcription and inhibiting epithelial-to-mesenchymal transition.
2019 American Journal of Medical Genetics John M. Opitz Young investigator Table 3. . Disorders to Consider in the Differential Diagnosis of SATB2-Associated Syndrome (SAS).
20. Adam MP, Ardinger HH, Pagon RA, et al., editors.
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(A) Quantitative RT–PCR for Satb1, Satb2, and Oct4 expression in Oct4-HygroTK wild-type ES cells grown for 3 d in the presence of hygromyin prior to differentiation.At day 6 of differentiation, gancyclovir was added in order to eliminate cells with active Oct4 expression. cDNA was prepared from total RNA at the indicated Boster Bio Anti-DNA-binding protein SATB2 SATB2 Antibody catalog # A02588-1.
Disorders to Consider in the Differential Diagnosis of SATB2-Associated Syndrome (SAS).
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Data indicate two special AT-rich sequence-binding protein 2 (SATB2) sequence variants in two unrelated patients presenting with Rett-like phenotypes. SATB2 is a DNA-binding protein that interacts with DNA matrix attachment regions to alter gene expression by inducing local chromatin remodeling. In contrast to TBR1, SOX5, and FEZF2, SATB2 controls the expression profiles, migration, and connectivity of intracortical projection neurons ( Fig. 6.3) ( Alcamo et al., 2008; Britanova et al., 2008 ). The SATB2 gene provides instructions for making a protein that is involved in the development of the brain and structures in the head and face.
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Physical form Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide. Preparation Note Summary of SATB2 (FLJ21474, KIAA1034) expression in human tissue. Selective nuclear expression in large intestine and subsets of neuronal cells in brain. SATB2 (SATB homeobox 2) active profile. The Function of SATB2.
The SATB2 protein directs development by controlling the activity of multiple genes in a coordinated fashion. 2008-02-07 · Inactivation of Satb2 leads to perinatal lethality most likely as a result of multiple craniofacial abnormalities (Britanova et al., 2006b, Dobreva et al., 2006). In a previous study, we identified Satb2 as a gene that is expressed predominantly in young UL neurons but not in SVZ progenitors (Britanova et al., 2005). SATB2 is a nuclear matrix attachment region-binding transcription factor with developmental role in craniofacial, neural, and osteoblastic differentiation. Several publications have documented SATB2 expression in the epithelium of the lower gastrointestinal tract (appendix, colon, and rectum). Aims: Special AT-rich sequence-binding protein 2 (SATB2) is a transcriptional regulator with critical roles in brain, craniofacial and skeletal development. It has emerged as a key marker of lower gastrointestinal (GI) tract columnar epithelial and osteoblastic differentiation.
In the adult In normal tissues, strong nuclear SATB2 expression is observed in essentially all glandular cells lining the lower gastrointestinal tract, including the appendix, 15 Dec 2020 Hence, interactions between SATB2 and the inner nuclear membrane protein LEMD2 influence gene expression programs in pyramidal neurons Special AT-rich sequence-binding protein 2 (SATB2) or DNA-binding protein SATB2 is a nuclear protein bound to DNA at nuclear matrix- or scaffold- associated SATB2 antibody has been identified as a tissue-specific protein when screening protein expression patterns in human and cancerous tissues, with expression SATB2 is a nuclear matrix attachment region-binding transcription factor with developmental role in craniofacial, neural, and osteoblastic differentiation.